Bruce A Beutler (Bruce Beutler)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 61

Top Topics

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature structural & molecular biology

The Journal of experimental medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology 31 (2) (2024)
Samantha K Teixeira, Roberto B Pontes, Luiz Fernando G Zuleta, Jianhui Wang, Darui Xu, Sara Hildebrand, Jamie Russell, Xiaoming Zhan, Mihwa Choi, Miao Tang, Xiaohong Li, Sara Ludwig, Bruce A Beutler, Jose Eduardo Krieger
Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping. Science advances 10 (9) (2024)
Xue Zhong, James J Moresco, Jeffrey A SoRelle, Ran Song, Yiao Jiang, Mylinh T Nguyen, Jianhui Wang, Chun Hui Bu, Eva Marie Y Moresco, Bruce A Beutler, Jin Huk Choi
Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (31) (2024)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO reports 25 (8) (2024)
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology 31 (2) (2024)
Xue Zhong, James J Moresco, Jeffrey A SoRelle, Ran Song, Yiao Jiang, Mylinh T Nguyen, Jianhui Wang, Chun Hui Bu, Eva Marie Y Moresco, Bruce A Beutler, Jin Huk Choi
Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (31) (2024)
Xue Zhong, Nagesh Peddada, James J Moresco, Jianhui Wang, Yiao Jiang, Jonathan J Rios, Eva Marie Y Moresco, Jin Huk Choi, Bruce A Beutler
Viable mutations of mouse midnolin suppress B cell malignancies. The Journal of experimental medicine 221 (6) (2024)
Samantha K Teixeira, Roberto B Pontes, Luiz Fernando G Zuleta, Jianhui Wang, Darui Xu, Sara Hildebrand, Jamie Russell, Xiaoming Zhan, Mihwa Choi, Miao Tang, Xiaohong Li, Sara Ludwig, Bruce A Beutler, Jose Eduardo Krieger
Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping. Science advances 10 (9) (2024)
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology 31 (2) (2024)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO reports 25 (8) (2024)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO reports 25 (8) (2024)
Xue Zhong, Nagesh Peddada, James J Moresco, Jianhui Wang, Yiao Jiang, Jonathan J Rios, Eva Marie Y Moresco, Jin Huk Choi, Bruce A Beutler
Viable mutations of mouse midnolin suppress B cell malignancies. The Journal of experimental medicine 221 (6) (2024)
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology (2024)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO reports (2024)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO reports (2024)
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology 31 (2) (2024)
Xue Zhong, Nagesh Peddada, James J Moresco, Jianhui Wang, Yiao Jiang, Jonathan J Rios, Eva Marie Y Moresco, Jin Huk Choi, Bruce A Beutler
Viable mutations of mouse midnolin suppress B cell malignancies. The Journal of experimental medicine 221 (6) (2024)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO reports 25 (8) (2024)
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology 31 (2) (2024)
Xue Zhong, James J Moresco, Jeffrey A SoRelle, Ran Song, Yiao Jiang, Mylinh T Nguyen, Jianhui Wang, Chun Hui Bu, Eva Marie Y Moresco, Bruce A Beutler, Jin Huk Choi
Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (31) (2024)
Xue Zhong, Nagesh Peddada, James J Moresco, Jianhui Wang, Yiao Jiang, Jonathan J Rios, Eva Marie Y Moresco, Jin Huk Choi, Bruce A Beutler
Viable mutations of mouse midnolin suppress B cell malignancies. The Journal of experimental medicine 221 (6) (2024)
Samantha K Teixeira, Roberto B Pontes, Luiz Fernando G Zuleta, Jianhui Wang, Darui Xu, Sara Hildebrand, Jamie Russell, Xiaoming Zhan, Mihwa Choi, Miao Tang, Xiaohong Li, Sara Ludwig, Bruce A Beutler, Jose Eduardo Krieger
Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping. Science advances 10 (9) (2024)
Xue Zhong, James J Moresco, Jeffrey A SoRelle, Ran Song, Yiao Jiang, Mylinh T Nguyen, Jianhui Wang, Chun Hui Bu, Eva Marie Y Moresco, Bruce A Beutler, Jin Huk Choi
Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (31) (2024)
Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y Moresco, Zhenguo Chen, Bruce A Beutler, Lei Sun
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2 . Nature structural & molecular biology (2024)
Seher Yüksel, Bogale Aredo, Yeshumenesh Zegeye, Cynthia X Zhao, Miao Tang, Xiaohong Li, John D Hulleman, Laurent Gautron, Sara Ludwig, Eva Marie Y Moresco, Igor A Butovich, Bruce A Beutler, Rafael L Ufret-Vincenty
Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis. Communications biology 6 (1) (2023)
Ran Song, William McAlpine, Aaron M Fond, Evan Nair-Gill, Jin Huk Choi, Elisabeth E L Nyström, Liisa Arike, Sydney Field, Xiaohong Li, Jeffrey A SoRelle, James J Moresco, Eva Marie Y Moresco, John Yates Iii, Parastoo Azadi, Josephine Ni, George M H Birchenough, Bruce A Beutler, Emre E Turer
Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Nature communications 14 (1) (2023)
Vikram Jakkamsetti, Qian Ma, Gustavo Angulo, William Scudder, Bruce A Beutler, Juan M Pascual
Genetic influences on motor learning and superperformance mutants revealed by random mutational survey of mouse locomotion. bioRxiv : the preprint server for biology (2023)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. bioRxiv : the preprint server for biology (2023)
Xue Zhong, Nagesh Peddada, Jianhui Wang, James J Moresco, Xiaowei Zhan, John M Shelton, Jeffrey A SoRelle, Katie Keller, Danielle Renee Lazaro, Eva Marie Y Moresco, Jin Huk Choi, Bruce A Beutler
OVOL2 sustains postnatal thymic epithelial cell identity. Nature communications 14 (1) (2023)
Seher Yüksel, Bogale Aredo, Yeshumenesh Zegeye, Cynthia X Zhao, Miao Tang, Xiaohong Li, John D Hulleman, Laurent Gautron, Sara Ludwig, Eva Marie Y Moresco, Igor A Butovich, Bruce A Beutler, Rafael L Ufret-Vincenty
Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis. Communications biology 6 (1) (2023)
Xue Zhong, James J Moresco, Katie Keller, Danielle Renee Lazaro, Claire Ely, Eva Marie Y Moresco, Bruce A Beutler, Jin Huk Choi
Essential requirement for IER3IP1 in B cell development. Proceedings of the National Academy of Sciences of the United States of America 120 (46) (2023)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. bioRxiv : the preprint server for biology (2023)
Jamie Russell, Luming Chen, Aijie Liu, Jianhui Wang, Subarna Ghosh, Xue Zhong, Hexin Shi, Bruce A Beutler, Evan Nair-Gill
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. bioRxiv : the preprint server for biology (2023)
Xue Zhong, James J Moresco, Jolene K Diedrich, Antonio M Pinto, Jeffrey A SoRelle, Jianhui Wang, Katie Keller, Sara Ludwig, Eva Marie Y Moresco, Bruce A Beutler, Jin Huk Choi
Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis. Proceedings of the National Academy of Sciences of the United States of America 120 (50) (2023)
Seher Yüksel, Bogale Aredo, Yeshumenesh Zegeye, Cynthia X Zhao, Miao Tang, Xiaohong Li, John D Hulleman, Laurent Gautron, Sara Ludwig, Eva Marie Y Moresco, Igor A Butovich, Bruce A Beutler, Rafael L Ufret-Vincenty
Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis. Communications biology 6 (1) (2023)
Xue Zhong, Jin Huk Choi, Sara Hildebrand, Sara Ludwig, Jianhui Wang, Evan Nair-Gill, Tzu-Chieh Liao, James J Moresco, Aijie Liu, Jiexia Quan, Qihua Sun, Duanwu Zhang, Xiaoming Zhan, Mihwa Choi, Xiaohong Li, Junmei Wang, Thomas Gallagher, Eva Marie Y Moresco, Bruce A Beutler
RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Proceedings of the National Academy of Sciences of the United States of America 119 (18) (2022)
Ivo Rimann, Rosana Gonzalez-Quintial, Roberto Baccala, William B Kiosses, John R Teijaro, Christopher G Parker, Xiaohong Li, Bruce A Beutler, Dwight H Kono, Argyrios N Theofilopoulos
The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes. Proceedings of the National Academy of Sciences of the United States of America 119 (14) (2022)
Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott, Jiexia Quan, Chun Hui Bu, Sara Hildebrand, Eva Marie Y Moresco, Jean-François Bach, Bruce A Beutler
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice. Disease models & mechanisms 15 (6) (2022)
Zhao Zhang, Yu Xun, Shunxing Rong, Lijuan Yan, Jeffrey A SoRelle, Xiaohong Li, Miao Tang, Katie Keller, Sara Ludwig, Eva Marie Y Moresco, Bruce A Beutler
Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Nature communications 13 (1) (2022)
Darui Xu, Stephen Lyon, Chun Hui Bu, Sara Hildebrand, Jin Huk Choi, Xue Zhong, Aijie Liu, Emre E Turer, Zhao Zhang, Jamie Russell, Sara Ludwig, Elena Mahrt, Evan Nair-Gill, Hexin Shi, Ying Wang, Duanwu Zhang, Tao Yue, Kuan-Wen Wang, Jeffrey A SoRelle, Lijing Su, Takuma Misawa, William McAlpine, Lei Sun, Jianhui Wang, Xiaoming Zhan, Mihwa Choi, Roxana Farokhnia, Andrew Sakla, Sara Schneider, Hannah Coco, Gabrielle Coolbaugh, Braden Hayse, Sara Mazal, Dawson Medler, Brandon Nguyen, Edward Rodriguez, Andrew Wadley, Miao Tang, Xiaohong Li, Priscilla Anderton, Katie Keller, Amanda Press, Lindsay Scott, Jiexia Quan, Sydney Cooper, Tiffany Collie, Baifang Qin, Jennifer Cardin, Rochelle Simpson, Meron Tadesse, Qihua Sun, Carol A Wise, Jonathan J Rios, Eva Marie Y Moresco, Bruce A Beutler
Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning. Proceedings of the National Academy of Sciences of the United States of America 118 (28) (2021)
Lijing Su, Muhammad Athamna, Ying Wang, Junmei Wang, Marina Freudenberg, Tao Yue, Jianhui Wang, Eva Marie Y Moresco, Haoming He, Tsaffrir Zor, Bruce A Beutler
Sulfatides are endogenous ligands for the TLR4-MD-2 complex. Proceedings of the National Academy of Sciences of the United States of America 118 (30) (2021)
Anne-Perrine Foray, Sophie Candon, Sara Hildebrand, Cindy Marquet, Fabrice Valette, Coralie Pecquet, Sebastien Lemoine, Francina Langa-Vives, Michael Dumas, Peipei Hu, Pere Santamaria, Sylvaine You, Stephen Lyon, Lindsay Scott, Chun Hui Bu, Tao Wang, Darui Xu, Eva Marie Y Moresco, Claudio Scazzocchio, Jean-François Bach, Bruce A Beutler, Lucienne Chatenoud
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America 118 (47) (2021)
Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla D Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y Moresco, Bruce A Beutler
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Nature communications 12 (1) (2021)
Tao Yue, Xiaoming Zhan, Duanwu Zhang, Ruchi Jain, Kuan-Wen Wang, Jin Huk Choi, Takuma Misawa, Lijing Su, Jiexia Quan, Sara Hildebrand, Darui Xu, Xiaohong Li, Emre E Turer, Lei Sun, Eva Marie Y Moresco, Bruce A Beutler
SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science (New York, N.Y.) 372 (6543) (2021)
Evan Nair-Gill, Massimo Bonora, Xue Zhong, Aijie Liu, Amber Miranda, Nathan Stewart, Sara Ludwig, Jamie Russell, Thomas Gallagher, Paolo Pinton, Bruce A Beutler
Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. The EMBO journal 40 (9) (2021)
Jeffrey A SoRelle, Zhe Chen, Jianhui Wang, Tao Yue, Jin Huk Choi, Kuan-Wen Wang, Xue Zhong, Sara Hildebrand, Jamie Russell, Lindsay Scott, Darui Xu, Xiaowei Zhan, Chun Hui Bu, Tao Wang, Mihwa Choi, Miao Tang, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Eva Marie Y Moresco, Bruce A Beutler
Dominant atopy risk mutations identified by mouse forward genetic analysis. Allergy 76 (4) (2020)
Takuma Misawa, Jeffrey A SoRelle, Jin Huk Choi, Tao Yue, Kuan-Wen Wang, William McAlpine, Jianhui Wang, Aijie Liu, Koichi Tabeta, Emre E Turer, Bret M Evers, Evan Nair-Gill, Subhajit Poddar, Lijing Su, Feiya Ou, Liyang Yu, Jamie Russell, Sara Ludwig, Xiaoming Zhan, Sara Hildebrand, Xiaohong Li, Miao Tang, Anne R Murray, Eva Marie Y Moresco, Bruce A Beutler
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation. Science immunology 5 (43) (2020)
Xue Zhong, Lijing Su, Yi Yang, Evan Nair-Gill, Miao Tang, Priscilla Anderton, Xiaohong Li, Jianhui Wang, Xiaoming Zhan, Diana R Tomchick, Chad A Brautigam, Eva Marie Y Moresco, Jin Huk Choi, Bruce A Beutler
Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function. Proceedings of the National Academy of Sciences of the United States of America 117 (15) (2020)
Jin Huk Choi, Jonghee Han, Panayotis C Theodoropoulos, Xue Zhong, Jianhui Wang, Dawson Medler, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Miao Tang, Thomas Gallagher, Gang Yu, Bruce A Beutler
Essential requirement for nicastrin in marginal zone and B-1 B cell development. Proceedings of the National Academy of Sciences of the United States of America 117 (9) (2020)
Bo Chen, Bogale Aredo, Yi Ding, Xin Zhong, Yuanfei Zhu, Cynthia X Zhao, Ashwani Kumar, Chao Xing, Laurent Gautron, Stephen Lyon, Jamie Russell, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Ludwig, Eva Marie Y Moresco, Bruce A Beutler, Rafael L Ufret-Vincenty
Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice. Proceedings of the National Academy of Sciences of the United States of America 117 (23) (2020)
Michele Carbone, Sarah T Arron, Bruce A Beutler, Angela Bononi, Webster Cavenee, James E Cleaver, Carlo M Croce, Alan D' Andrea, William D Foulkes, Giovanni Gaudino, Joanna L Groden, Elizabeth P Henske, Ian D Hickson, Paul M Hwang, Richard D Kolodner, Tak W Mak, David Malkin, Raymond J Monnat, Flavia Novelli, Harvey I Pass, John H Petrini, Laura S Schmidt, Haining Yang
Tumour predisposition and cancer syndromes as models to study gene-environment interactions. Nature reviews. Cancer 20 (9) (2020)
Zhao Zhang, Thomas Gallagher, Jan-Bernd Funcke, Bruce A Beutler
Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome. Proceedings of the National Academy of Sciences of the United States of America 117 (21) (2020)
Kuan-Wen Wang, Xiaoming Zhan, William McAlpine, Zhao Zhang, Jin Huk Choi, Hexin Shi, Takuma Misawa, Tao Yue, Duanwu Zhang, Ying Wang, Sara Ludwig, Jamie Russell, Miao Tang, Xiaohong Li, Anne R Murray, Eva Marie Y Moresco, Emre E Turer, Bruce A Beutler
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 116 (23) (2019)
Duanwu Zhang, Tao Yue, Jin Huk Choi, Evan Nair-Gill, Xue Zhong, Kuan-Wen Wang, Xiaoming Zhan, Xiaohong Li, Mihwa Choi, Miao Tang, Jiexia Quan, Sara Hildebrand, Eva Marie Y Moresco, Bruce A Beutler
Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40. Nature immunology 20 (10) (2019)
Meng Deng, Haitao Guo, Jason W Tam, Brandon M Johnson, W June Brickey, James S New, Austin Lenox, Hexin Shi, Douglas T Golenbock, Beverly H Koller, Karen P McKinnon, Bruce A Beutler, Jenny P Y Ting
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR. The Journal of experimental medicine 216 (12) (2019)
Lirui Wang, Magdalena Mazagova, Chuyue Pan, Song Yang, Katharina Brandl, Jun Liu, Shannon M Reilly, Yanhan Wang, Zhaorui Miao, Rohit Loomba, Na Lu, Qinglong Guo, Jihua Liu, Ruth T Yu, Michael Downes, Ronald M Evans, David A Brenner, Alan R Saltiel, Bruce A Beutler, Bernd Schnabl
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proceedings of the National Academy of Sciences of the United States of America 116 (30) (2019)
Jin Huk Choi, Xue Zhong, William McAlpine, Tzu-Chieh Liao, Duanwu Zhang, Beibei Fang, Jamie Russell, Sara Ludwig, Evan Nair-Gill, Zhao Zhang, Kuan-Wen Wang, Takuma Misawa, Xiaoming Zhan, Mihwa Choi, Tao Wang, Xiaohong Li, Miao Tang, Qihua Sun, Liyang Yu, Anne R Murray, Eva Marie Y Moresco, Bruce A Beutler
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science (New York, N.Y.) 364 (6440) (2019)
William McAlpine, Lei Sun, Kuan-Wen Wang, Aijie Liu, Ruchi Jain, Miguel San Miguel, Jianhui Wang, Zhao Zhang, Braden Hayse, Sarah Grace McAlpine, Jin Huk Choi, Xue Zhong, Sara Ludwig, Jamie Russell, Xiaoming Zhan, Mihwa Choi, Xiaohong Li, Miao Tang, Eva Marie Y Moresco, Bruce A Beutler, Emre Turer
Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. Proceedings of the National Academy of Sciences of the United States of America 115 (49) (2018)
William McAlpine, Kuan-Wen Wang, Jin Huk Choi, Miguel San Miguel, Sarah Grace McAlpine, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Xiaoming Zhan, Mihwa Choi, Tao Wang, Chun Hui Bu, Anne R Murray, Eva Marie Y Moresco, Emre E Turer, Bruce A Beutler
The class I myosin MYO1D binds to lipid and protects against colitis. Disease models & mechanisms 11 (9) (2018)
Emre E Turer, Miguel San Miguel, Kuan-Wen Wang, William McAlpine, Feiya Ou, Xiaohong Li, Miao Tang, Zhao Zang, Jianhui Wang, Braden Hayse, Bret Evers, Xiaoming Zhan, Jamie Russell, Bruce A Beutler
A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis. Disease models & mechanisms 11 (12) (2018)
Lei Sun, Zhengfan Jiang, Victoria A Acosta-Rodriguez, Michael Berger, Xin Du, Jin Huk Choi, Jianhui Wang, Kuan-Wen Wang, Gokhul K Kilaru, Jennifer A Mohawk, Jiexia Quan, Lindsay Scott, Sara Hildebrand, Xiaohong Li, Miao Tang, Xiaoming Zhan, Anne R Murray, Diantha La Vine, Eva Marie Y Moresco, Joseph S Takahashi, Bruce A Beutler
HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. The Journal of experimental medicine 214 (11) (2017)