Chen-Yong Lin

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 15

Top Venues

Human cell

Human molecular genetics

PloS one

Glycobiology

Georgetown University

Georgetown University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Georgetown University

United States

Research Associate Professor :: Lombardi Comprehensive Cancer Center

Education History

Georgetown University

United States

PHD :: Cell Biology

Publications

Nanxi Huang, Qiaochu Wang, Robert B Bernard, Chao-Yang Chen, Je-Ming Hu, Jehng-Kang Wang, Khee-Siang Chan, Michael D Johnson, Chen-Yong Lin
SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation. Human molecular genetics 33 (9) (2024)
Nanxi Huang, Qiaochu Wang, Robert B Bernard, Chao-Yang Chen, Je-Ming Hu, Jehng-Kang Wang, Khee-Siang Chan, Michael D Johnson, Chen-Yong Lin
SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation. Human molecular genetics (2024)
Nanxi Huang, Qiaochu Wang, Robert B Bernard, Chao-Yang Chen, Je-Ming Hu, Jehng-Kang Wang, Khee-Siang Chan, Michael D Johnson, Chen-Yong Lin
SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation. Human molecular genetics 33 (9) (2024)
Nanxi Huang, Qiaochu Wang, Chao-Yang Chen, Je-Ming Hu, Jehng-Kang Wang, Ping-Ying Chang, Michael D Johnson, Chen-Yong Lin
N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity. Glycobiology (2023)
Dajun D Lu, Nanxi Huang, Sheng-Wen A Li, Jessica R Fang, Chih-Hsin Lai, Jehng-Kang Wang, Khee-Siang Chan, Michael D Johnson, Chen-Yong Lin
HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes. Human cell (2023)
Robert B Barndt, Mon-Juan Lee, Nanxi Huang, Dajun D Lu, See-Chi Lee, Po-Wen Du, Chun-Chia Chang, Ping-Feng B Tsai, Yu-Siou K Huang, Hao-Ming Chang, Jehng-Kang Wang, Chih-Hsin Lai, Michael D Johnson, Chen-Yong Lin
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells. Human molecular genetics 30 (19) (2022)
Dajun D Lu, Yayun Gu, Sheng-Wen A Li, Robert J Barndt, Shih-Ming Huang, Jehng-Kang Wang, Hui Chen Su, Michael D Johnson, Chen-Yong Lin
Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes. Human cell 34 (3) (2021)
Nanxi Huang, Robert B Barndt, Dajun D Lu, Qiaochu Wang, Shih-Ming Huang, Jehng-Kang Wang, Ping-Ying Chang, Chao-Yang Chen, Je-Ming Hu, Hui-Chen Su, Michael D Johnson, Chen-Yong Lin
The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2. Human cell (2021)
Shun-Cheng Chang, Chien-Ping Chiang, Chih-Hsin Lai, Po-Wen A Du, Yu-Sin Hung, Yu-Hsuan Chen, Hui-Yu Yang, Hao-Yu Fang, Shiao-Pieng Lee, Hung-Jen Tang, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin. Human cell 33 (4) (2020)
Chun-Che Tseng, Bailing Jia, Robert B Barndt, Yang-Hong Dai, Yu Hsin Chen, Po-Wen A Du, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D Johnson
The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane. PloS one 15 (2) (2020)
Chen-Yong Lin, Jehng-Kang Wang, Michael D Johnson
The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation. Human cell 33 (3) (2020)
Bailing Jia, Hamishi A Thompson, Robert B Barndt, Yi-Lin Chiu, Mon-Juan Lee, See-Chi Lee, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D Johnson
Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation. Human cell 33 (4) (2020)
Shiao-Pieng Lee, Chen-Yu Kao, Shun-Cheng Chang, Yi-Lin Chiu, Yen-Ju Chen, Ming-Hsing G Chen, Chun-Chia Chang, Yu-Wen Lin, Chien-Ping Chiang, Jehng-Kang Wang, Chen-Yong Lin, Michael D Johnson
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin. PloS one 13 (2) (2018)
Frank Shiao, Li-Ching O Liu, Nanxi Huang, Ying-Jung J Lai, Robert J Barndt, Chun-Che Tseng, Jehng-Kang Wang, Bailing Jia, Michael D Johnson, Chen-Yong Lin
Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2. PloS one 12 (1) (2017)
Chun-Che Tseng, Bailing Jia, Robert Barndt, Yayun Gu, Chien-Yu Chen, I-Chu Tseng, Sheng-Fang Su, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity. PloS one 12 (8) (2017)

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Publication Activity (10 Years)

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Chen-Yong Lin