Hans-Georg Lerchen

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 8

Top Topics

Diffusion Weighted

Top Venues

Chemistry (Weinheim an der Bergstrasse, Germany)

Angewandte Chemie (International ed. in English)

The Journal of organic chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Melanie Heroult, Dmitry Zubov, Kersten Matthias Gericke, Harvey Wong, Melanie M Frigault, Amy J Johnson, Raquel Izumi, Ahmed Hamdy
Discovery of VIP236, an αvβ3-Targeted Small-Molecule-Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors. Cancers 15 (17) (2023)
Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Charlotte Kopitz, Melanie Heroult, Dmitry Zubov, Joerg Willuda, Thomas Schlange, Antje Kahnert, Harvey Wong, Raquel Izumi, Ahmed Hamdy
A Small Molecule-Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α V ß 3 Binder for the Treatment of Multiple Cancer Types. Cancers 14 (2) (2022)
Dennis Kirchhoff, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Antje Margret Wengner, Oliver von Ahsen, Pascale Buchmann, Stephan Märsch, Christoph Mahlert, Simone Greven, Lisa Dietz, Michael Erkelenz, Ruprecht Zierz, Sandra Johanssen, Dominik Mumberg, Anette Sommer
IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies. Cancers 12 (11) (2020)
Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Anette Sommer, Sandra Berndt, Anne-Sophie Rebstock, Sarah Johannes, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jörißen
Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads. Bioconjugate chemistry 31 (8) (2020)
Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Sandra Berndt, Anette Sommer, Lisa Dietz, Anne-Sophie Rebstock, Sarah Johannes, Leo Marx, Hannah Jörißen, Christoph Mahlert, Simone Greven
Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (35) (2019)
Paul Hoppenz, Sylvia Els-Heindl, Martin Kellert, Robert Kuhnert, Stefan Saretz, Hans-Georg Lerchen, Johannes Köbberling, Bernd Riedl, Evamarie Hey-Hawkins, Annette G Beck-Sickinger
A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy. The Journal of organic chemistry 85 (3) (2019)
André Raposo Moreira Dias, Arianna Pina, Amelia Dean, Hans-Georg Lerchen, Michele Caruso, Fabio Gasparri, Ivan Fraietta, Sonia Troiani, Daniela Arosio, Laura Belvisi, Luca Pignataro, Alberto Dal Corso, Cesare Gennari
Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (7) (2018)
Hans-Georg Lerchen, Sven Wittrock, Beatrix Stelte-Ludwig, Anette Sommer, Sandra Berndt, Nils Griebenow, Anne-Sophie Rebstock, Sarah Johannes, Yolanda Cancho-Grande, Christoph Mahlert, Simone Greven, Carsten Terjung
Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class. Angewandte Chemie (International ed. in English) 57 (46) (2018)