Jacek Otlewski

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 25

Top Topics

Signaling Pathway

Tyrosine Kinase

Top Venues

International journal of molecular sciences

Molecular pharmaceutics

Biomacromolecules

This page only lists publications with an associated author ORCID identifier.

Publications

Daria Nawrocka, Mateusz Adam Krzyscik, Katarzyna Dominika Sluzalska, Jacek Otlewski
Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1. International journal of molecular sciences 24 (12) (2023)
Daria Nawrocka, Mateusz Adam Krzyscik, Katarzyna Dominika Sluzalska, Jacek Otlewski
Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1. International journal of molecular sciences 24 (12) (2023)
Jakub Szymczyk, Aleksandra Czyrek, Jacek Otlewski, Malgorzata Zakrzewska
FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway. Biomedicines 11 (7) (2023)
Martyna Biadun, Martyna Sochacka, Radoslaw Karelus, Karolina Baran, Aleksandra Czyrek, Jacek Otlewski, Daniel Krowarsch, Lukasz Opalinski, Malgorzata Zakrzewska
FGF homologous factors are secreted from cells to induce FGFR-mediated anti-apoptotic response. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37 (7) (2023)
Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sørensen, Jakub Szymczyk, Katarzyna Dominika Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewska
Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS 80 (10) (2023)
Daria Nawrocka, Mateusz Adam Krzyscik, Katarzyna Dominika Sluzalska, Jacek Otlewski
Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1. International journal of molecular sciences 24 (12) (2023)
Marta Poźniak, Dominika Żukowska, Aleksandra Gędaj, Mateusz Adam Krzyscik, Natalia Porębska, Malgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases. International journal of molecular sciences 23 (15) (2022)
Karolina Jendryczko, Jakub Rzeszotko, Mateusz Adam Krzyscik, Anna Kocyła, Jakub Szymczyk, Jacek Otlewski, Anna Szlachcic
Drug Conjugation via Maleimide-Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies. Molecular pharmaceutics 19 (5) (2022)
Martyna Sochacka, Radoslaw Karelus, Lukasz Opalinski, Daniel Krowarsch, Martyna Biadun, Jacek Otlewski, Malgorzata Zakrzewska
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex. Cell communication and signaling : CCS 20 (1) (2022)
Agata Lampart, Katarzyna Dominika Sluzalska, Aleksandra Czyrek, Aleksandra Szerszen, Jacek Otlewski, Antoni Wiedlocha, Malgorzata Zakrzewska
Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. Cells 11 (3) (2022)
Isabella Damiani, Silvia Castiglioni, Alicja Sochaj-Gregorczyk, Fabrizia Bonacina, Irma Colombo, Valentina Rusconi, Jacek Otlewski, Alberto Corsini, Stefano Bellosta
Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells. Biology 10 (8) (2021)
Natalia Porębska, Agata Knapik, Marta Poźniak, Mateusz Adam Krzyscik, Małgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski
Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers. Biomacromolecules (2021)
Jakub Szymczyk, Katarzyna Dominika Sluzalska, Izabela Materla, Lukasz Opalinski, Jacek Otlewski, Malgorzata Zakrzewska
FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance. Cancers 13 (22) (2021)
Marta Poźniak, Weronika Zarzycka, Natalia Porębska, Agata Knapik, Paulina Marczakiewicz-Perera, Malgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs. Biomolecules 11 (8) (2021)
Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Vigdis Sørensen, Geir Frode Øy, Skjalg Brunheim, Ellen M Haugsten, Gunhild M Mælandsmo, Antoni Wiedlocha, Jacek Otlewski
Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model. Biomacromolecules 22 (10) (2021)
Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Jacek Otlewski
Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1). Molecular pharmaceutics 17 (7) (2020)
Karolina Jendryczko, Julia Chudzian, Natalia Skinder, Łukasz Opaliński, Jakub Rzeszótko, Antoni Wiedlocha, Jacek Otlewski, Anna Szlachcic
FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1. Cancers 12 (10) (2020)
Daria Nawrocka, Mateusz Adam Krzyscik, Łukasz Opaliński, Malgorzata Zakrzewska, Jacek Otlewski
Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential. International journal of molecular sciences 21 (11) (2020)
Mateusz Adam Krzyscik, Łukasz Opaliński, Jacek Otlewski
Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation. Molecular pharmaceutics 16 (8) (2019)
Anna Szlachcic, Martyna Sochacka, Aleksandra Czyrek, Lukasz Opalinski, Daniel Krowarsch, Jacek Otlewski, Malgorzata Zakrzewska
Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity. Cells 8 (8) (2019)
Malgorzata Zakrzewska, Lukasz Opalinski, Ellen M Haugsten, Jacek Otlewski, Antoni Wiedlocha
Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling. International journal of molecular sciences 20 (8) (2019)
Karolina Weronika Świderska, Anna Szlachcic, Łukasz Opaliński, Malgorzata Zakrzewska, Jacek Otlewski
FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1. International journal of molecular sciences 19 (7) (2018)
Anna M Serwotka-Suszczak, Alicja M Sochaj-Gregorczyk, Jerzy Pieczykolan, Daniel Krowarsch, Filip Jelen, Jacek Otlewski
Correction: Serwotka-Suszczak, A. M. et al. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells. Int. J. Mol. Sci. 2017, 18, 401. International journal of molecular sciences 19 (11) (2018)
Julia Chudzian, Anna Szlachcic, Malgorzata Zakrzewska, Miroslawa Czub, Marcin Pustula, Tad A Holak, Jacek Otlewski
Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity. International journal of molecular sciences 19 (9) (2018)
Natalia Porębska, Marta Latko, Marika Kucińska, Malgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński
Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment. Journal of clinical medicine 8 (1) (2018)