John F X Diffley (John Fx Diffley)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 26

Top Venues

The Biochemical journal

Nature structural & molecular biology

Nature communications

eLife

Francis Crick Institute

New York University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Francis Crick Institute Jan 01 2015

United Kingdom

Associate Research Director :: Clare Hall Laboratory

London Research Institute Feb 04 2002 - Apr 01 2015

United Kingdom

Senior Scientist :: Clare Hall Laboratories

London Research Institute Jan 01 2006

United Kingdom

Deputy Director, LRI :: Clare Hall Laboratories

London Research Institute Jan 01 2006

United Kingdom

Director, Clare Hall Labs :: Clare Hall Laboratories

Imperial Cancer Research Fund - Feb 04 2002

United Kingdom

Principal Scientist :: Clare Hall Laboratories

Imperial Cancer Research Fund

United Kingdom

Senior Group Leader :: Clare Hall Laboratories

Imperial Cancer Research Fund

United Kingdom

Junior Group Leader :: Clare Hall Laboratories

Cold Spring Harbor Laboratory

United States

Postdoctoral Fellow

Education History

New York University

United States

PHD :: Biology

Publications

Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis, Allison W McClure, Julia F Greiwe, Giacomo Palm, Andrea Nans, John F X Diffley, Alessandro Costa
Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology (2024)
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis, Allison W McClure, Julia F Greiwe, Giacomo Palm, Andrea Nans, John F X Diffley, Alessandro Costa
Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology 31 (8) (2024)
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis, Allison W McClure, Julia F Greiwe, Giacomo Palm, Andrea Nans, John F X Diffley, Alessandro Costa
Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology (2024)
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis, Allison W McClure, Julia F Greiwe, Giacomo Palm, Andrea Nans, John F X Diffley, Alessandro Costa
Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology 31 (8) (2024)
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis, Allison W McClure, Julia F Greiwe, Giacomo Palm, Andrea Nans, John F X Diffley, Alessandro Costa
Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology (2024)
Sarah S Henrikus, Marta H Gross, Oliver Willhoft, Thomas Pühringer, Jacob S Lewis, Allison W McClure, Julia F Greiwe, Giacomo Palm, Andrea Nans, John F X Diffley, Alessandro Costa
Unwinding of a eukaryotic origin of replication visualized by cryo-EM. Nature structural & molecular biology 31 (8) (2024)
Daniel Ramírez Montero, Humberto Sánchez, Edo van Veen, Theo van Laar, Belén Solano, John F X Diffley, Nynke H Dekker
Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation. Nature communications 14 (1) (2023)
Humberto Sánchez, Zhaowei Liu, Edo van Veen, Theo van Laar, John F X Diffley, Nynke H Dekker
A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint. Nature communications 14 (1) (2023)
Jacob S Lewis, Marta H Gross, Joana Sousa, Sarah S Henrikus, Julia F Greiwe, Andrea Nans, John F X Diffley, Alessandro Costa
Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature 606 (7916) (2022)
Jasmin Philip, Mihkel Örd, Andriele Silva, Shaneen Singh, John F X Diffley, Dirk Remus, Mart Loog, Amy E. Ikui
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae . eLife 11 (2022)
Agustina P Bertolin, Florian Weissmann, Jingkun Zeng, Viktor Posse, Jennifer C Milligan, Berta Canal, Rachel Ulferts, Mary Wu, Lucy S Drury, Michael Howell, Rupert Beale, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase. The Biochemical journal 478 (13) (2021)
Berta Canal, Allison W McClure, Joseph F Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P Bertolin, Jennifer C Milligan, Souradeep Basu, Lucy S Drury, Tom D Deegan, Ryo Fujisawa, Emma L Roberts, Clovis Basier, Karim P M Labib, Rupert Beale, Michael Howell, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. The Biochemical journal 478 (13) (2021)
Souradeep Basu, Tiffany Mak, Rachel Ulferts, Mary Wu, Tom Deegan, Ryo Fujisawa, Kang Wei Tan, Chew Theng Lim, Clovis Basier, Berta Canal, Joseph F Curran, Lucy S Drury, Allison W McClure, Emma L Roberts, Florian Weissmann, Theresa U Zeisner, Rupert Beale, Victoria H Cowling, Michael Howell, Karim P M Labib, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. The Biochemical journal 478 (13) (2021)
Max E Douglas, John F X Diffley
Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro. Nucleic acids research 49 (10) (2021)
Allison W McClure, John F X Diffley
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation. eLife 10 (2021)
Julia F Greiwe, Thomas C R Miller, Julia Locke, Fabrizio Martino, Steven Howell, Anne Schreiber, Andrea Nans, John F X Diffley, Alessandro Costa
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nature structural & molecular biology 29 (1) (2021)
John F X Diffley
Author's overview: identifying SARS-CoV-2 antiviral compounds. The Biochemical journal 478 (13) (2021)
Humberto Sánchez, Kaley McCluskey, Theo van Laar, Edo van Veen, Filip M Asscher, Belén Solano, John F X Diffley, Nynke H Dekker
DNA replication origins retain mobile licensing proteins. Nature communications 12 (1) (2021)
Chew Theng Lim, Kang Wei Tan, Mary Wu, Rachel Ulferts, Lee A Armstrong, Eiko Ozono, Lucy S Drury, Jennifer C Milligan, Theresa U Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu, Karim P M Labib, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. The Biochemical journal 478 (13) (2021)
Jennifer C Milligan, Theresa U Zeisner, George Papageorgiou, Dhira Joshi, Christelle Soudy, Rachel Ulferts, Mary Wu, Chew Theng Lim, Kang Wei Tan, Florian Weissmann, Berta Canal, Ryo Fujisawa, Tom Deegan, Hema Nagaraj, Ganka Bineva-Todd, Clovis Basier, Joseph F Curran, Michael Howell, Rupert Beale, Karim P M Labib, Nicola O'Reilly, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease. The Biochemical journal 478 (13) (2021)
Jingkun Zeng, Florian Weissmann, Agustina P Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase. The Biochemical journal 478 (13) (2021)
Berta Canal, Ryo Fujisawa, Allison W McClure, Tom D Deegan, Mary Wu, Rachel Ulferts, Florian Weissmann, Lucy S Drury, Agustina P Bertolin, Jingkun Zeng, Rupert Beale, Michael Howell, Karim P M Labib, John F X Diffley
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease. The Biochemical journal 478 (13) (2021)
Gideon Coster, John F X Diffley
Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading. Science (New York, N.Y.) 357 (6348) (2018)
Belén Gómez-González, Harshil Patel, Anne Early, John F X Diffley
Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants. Genetics 211 (2) (2018)
Ferdos Abid Ali, Max E Douglas, Julia Locke, Valerie E Pye, Andrea Nans, John F X Diffley, Alessandro Costa
Cryo-EM structure of a licensed DNA replication origin. Nature communications 8 (1) (2017)
Jin Chuan Zhou, Agnieszka Janska, Panchali Goswami, Ludovic Renault, Ferdos Abid Ali, Abhay Kotecha, John F X Diffley, Alessandro Costa
CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome. Proceedings of the National Academy of Sciences of the United States of America 114 (16) (2017)

John F X Diffley.css-eqlu8i{font-size:small;padding-left:4px;} (John Fx Diffley)

Publication Activity (10 Years)

Top Topics

Top Venues

John F X Diffley (John Fx Diffley)