Reinhard Lührmann

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 22

Top Topics

Electron Microscopy

Induced Pluripotent Stem Cells

Protein Protein

Top Venues

The EMBO journal

Nature communications

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton Jóse Rosas Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F Inglehearn, Martin McKibbin, Reinhard Lührmann, David H Steel, David J Elliott, Lyle Armstrong, Henning Urlaub, Robin R Ali, Sushma-Nagaraja Grellscheid, Colin A Johnson, Sina Mozaffari-Jovin, Majlinda Lako
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature communications 15 (1) (2024)
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton Jóse Rosas Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F Inglehearn, Martin McKibbin, Reinhard Lührmann, David H Steel, David J Elliott, Lyle Armstrong, Henning Urlaub, Robin R Ali, Sushma-Nagaraja Grellscheid, Colin A Johnson, Sina Mozaffari-Jovin, Majlinda Lako
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature communications 15 (1) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630 (8018) (2024)
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton Jóse Rosas Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F Inglehearn, Martin McKibbin, Reinhard Lührmann, David H Steel, David J Elliott, Lyle Armstrong, Henning Urlaub, Robin R Ali, Sushma-Nagaraja Grellscheid, Colin A Johnson, Sina Mozaffari-Jovin, Majlinda Lako
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature communications 15 (1) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630 (8018) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Henning Urlaub, Holger Stark, Reinhard Lührmann
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO journal 43 (6) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Henning Urlaub, Holger Stark, Reinhard Lührmann
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO journal 43 (6) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Henning Urlaub, Holger Stark, Reinhard Lührmann
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO journal 43 (6) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630 (8018) (2024)
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton Jóse Rosas Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F Inglehearn, Martin McKibbin, Reinhard Lührmann, David H Steel, David J Elliott, Lyle Armstrong, Henning Urlaub, Robin R Ali, Sushma-Nagaraja Grellscheid, Colin A Johnson, Sina Mozaffari-Jovin, Majlinda Lako
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature communications 15 (1) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630 (8018) (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Henning Urlaub, Holger Stark, Reinhard Lührmann
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO journal (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature (2024)
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Jiayun Zhong, Sebastian E J Ludwig, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630 (8018) (2024)
Olexandr Dybkov, Florian Heyd, Leyla El Ayoubi, Vivi-Yun Feng, Caroline Harnisch, Kilian Merz, Paula Leupold, Peter Yudichev, Dmitry E Agafonov, Cindy L Will, Cyrille Girard, Christian Dienemann, Henning Urlaub, Berthold Kastner, Florian Heyd, Reinhard Lührmann
Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Science advances 9 (9) (2023)
Olexandr Dybkov, Florian Heyd, Leyla El Ayoubi, Vivi-Yun Feng, Caroline Harnisch, Kilian Merz, Paula Leupold, Peter Yudichev, Dmitry E Agafonov, Cindy L Will, Cyrille Girard, Christian Dienemann, Henning Urlaub, Berthold Kastner, Florian Heyd, Reinhard Lührmann
Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Science advances 9 (9) (2023)
Olexandr Dybkov, Florian Heyd, Leyla El Ayoubi, Vivi-Yun Feng, Caroline Harnisch, Kilian Merz, Paula Leupold, Peter Yudichev, Dmitry E Agafonov, Cindy L Will, Cyrille Girard, Christian Dienemann, Henning Urlaub, Berthold Kastner, Florian Heyd, Reinhard Lührmann
Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Science advances 9 (9) (2023)
Zhenwei Zhang, Norbert Rigo, Olexandr Dybkov, Jean-Baptiste Fourmann, Cindy L Will, Vinay Kumar, Henning Urlaub, Holger Stark, Reinhard Lührmann
Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596 (7871) (2021)
Cole Townsend, Majety N Leelaram, Dmitry E Agafonov, Olexandr Dybkov, Cindy L Will, Karl Bertram, Henning Urlaub, Berthold Kastner, Holger Stark, Reinhard Lührmann
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science (New York, N.Y.) 370 (6523) (2020)
Anzhalika Sidarovich, Cindy L Will, Maria M Anokhina, Javier Ceballos, Sonja Sievers, Dmitry E Agafonov, Timur Samatov, Penghui Bao, Berthold Kastner, Henning Urlaub, Herbert Waldmann, Reinhard Lührmann
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6 (2017)