Sean F Brady

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 32

Top Topics

Network Analysis

Single Molecule

Circulating Tumor

Top Venues

Angewandte Chemie (International ed. in English)

Nature communications

Organic letters

This page only lists publications with an associated author ORCID identifier.

Publications

Zongqiang Wang, Amanda Kasper, Mai Takahashi, Adrian Morales Amador, Abir Bhattacharjee, Jingbo Kan, Yozen Hernandez, Melinda Ternei, Sean F Brady
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics. Angewandte Chemie (International ed. in English) 63 (17) (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature 629 (8011) (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature 629 (8011) (2024)
Jingbo Kan, Adrian Morales, Yozen Hernandez, Melinda A Ternei, Christophe Lemetre, Logan W Maclntyre, Nicolas Biais, Sean F Brady
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity. bioRxiv : the preprint server for biology (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature (2024)
Jingbo Kan, Adrian Morales, Yozen Hernandez, Melinda A Ternei, Christophe Lemetre, Logan W Maclntyre, Nicolas Biais, Sean F Brady
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity. bioRxiv : the preprint server for biology (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature 629 (8011) (2024)
Logan W MacIntyre, Bimal Koirala, Adam F Rosenzweig, Adrián Morales-Amador, Sean F Brady
Cinnamosyn, a Cinnamoylated Synthetic-Bioinformatic Natural Product with Cytotoxic Activity. Organic letters 26 (21) (2024)
Logan W MacIntyre, Bimal Koirala, Adam F Rosenzweig, Adrián Morales-Amador, Sean F Brady
Cinnamosyn, a Cinnamoylated Synthetic-Bioinformatic Natural Product with Cytotoxic Activity. Organic letters 26 (21) (2024)
Zongqiang Wang, Amanda Kasper, Mai Takahashi, Adrian Morales Amador, Abir Bhattacharjee, Jingbo Kan, Yozen Hernandez, Melinda Ternei, Sean F Brady
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics. Angewandte Chemie (International ed. in English) 63 (17) (2024)
Jingbo Kan, Adrian Morales, Yozen Hernandez, Melinda A Ternei, Christophe Lemetre, Logan W Maclntyre, Nicolas Biais, Sean F Brady
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity. bioRxiv : the preprint server for biology (2024)
Logan W MacIntyre, Bimal Koirala, Adam F Rosenzweig, Adrián Morales-Amador, Sean F Brady
Cinnamosyn, a Cinnamoylated Synthetic-Bioinformatic Natural Product with Cytotoxic Activity. Organic letters (2024)
Zongqiang Wang, Amanda Kasper, Mai Takahashi, Adrian Morales Amador, Abir Bhattacharjee, Jingbo Kan, Yozen Hernandez, Melinda Ternei, Sean F Brady
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics. Angewandte Chemie (International ed. in English) 63 (17) (2024)
Zongqiang Wang, Amanda Kasper, Mai Takahashi, Adrian Morales Amador, Abir Bhattacharjee, Jingbo Kan, Yozen Hernandez, Melinda Ternei, Sean F Brady
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics. Angewandte Chemie (International ed. in English) 63 (17) (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature 629 (8011) (2024)
Zongqiang Wang, Amanda Kasper, Mai Takahashi, Adrian Morales Amador, Abir Bhattacharjee, Jingbo Kan, Yozen Hernandez, Melinda Ternei, Sean F Brady
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics. Angewandte Chemie (International ed. in English) 63 (17) (2024)
Zongqiang Wang, Amanda Kasper, Mai Takahashi, Adrian Morales Amador, Abir Bhattacharjee, Jingbo Kan, Yozen Hernandez, Melinda Ternei, Sean F Brady
Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics. Angewandte Chemie (International ed. in English) (2024)
Amer A Hossain, Ying Z Pigli, Christian F Baca, Søren Heissel, Alexis Thomas, Vincent K Libis, Ján Burian, Joshua S Chappie, Sean F Brady, Phoebe A Rice, Luciano A Marraffini
DNA glycosylases provide antiviral defence in prokaryotes. Nature 629 (8011) (2024)
Dalton V Banh, Cameron G Roberts, Adrián Morales-Amador, Brandon A Berryhill, Waqas Chaudhry, Bruce R Levin, Sean F Brady, Luciano A Marraffini
Author Correction: Bacterial cGAS senses a viral RNA to initiate immunity. Nature (2023)
Dalton V Banh, Cameron G Roberts, Adrián Morales-Amador, Brandon A Berryhill, Waqas Chaudhry, Bruce R Levin, Sean F Brady, Luciano A Marraffini
Bacterial cGAS senses a viral RNA to initiate immunity. Nature (2023)
Zongqiang Wang, Bimal Koirala, Yözen Hernández, Matthew D Zimmerman, Sean F Brady
Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance. Science (New York, N.Y.) 376 (6596) (2022)
Zongqiang Wang, Nicholas Forelli, Yözen Hernández, Melinda A Ternei, Sean F Brady
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis. Nature communications 13 (1) (2022)
Ján Burian, Vincent K Libis, Yozen A Hernandez, Liliana Guerrero-Porras, Melinda A Ternei, Sean F Brady
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi. Nature biotechnology (2022)
Louis J Cohen, Sun M Han, Pearson Lau, Daniela Guisado, Yupu Liang, Toshiki G Nakashige, Thamina Ali, David Chiang, Adeeb Rahman, Sean F Brady
Unraveling function and diversity of bacterial lectins in the human microbiome. Nature communications 13 (1) (2022)
Zongqiang Wang, Bimal Koirala, Yözen Hernández, Matthew Zimmerman, Steven Park, David S Perlin, Sean F Brady
A naturally inspired antibiotic to target multidrug-resistant pathogens. Nature 601 (7894) (2022)
Vincent K Libis, Logan W MacIntyre, Rabia Mehmood, Liliana Guerrero, Melinda A Ternei, Niv Antonovsky, Ján Burian, Zongqiang Wang, Sean F Brady
Multiplexed mobilization and expression of biosynthetic gene clusters. Nature communications 13 (1) (2022)
Zongqiang Wang, Amanda Kasper, Rabia Mehmood, Melinda Ternei, Shaogang Li, Joel S Freundlich, Sean F Brady
Metagenome-Guided Analogue Synthesis Yields Improved Gram-Negative-Active Albicidin- and Cystobactamid-Type Antibiotics. Angewandte Chemie (International ed. in English) 60 (41) (2021)
Lei Li, Bimal Koirala, Yözen Hernández, Logan W MacIntyre, Melinda A Ternei, Riccardo Russo, Sean F Brady
Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens. Nature microbiology 7 (1) (2021)
Vincent K Libis, Niv Antonovsky, Mengyin Zhang, Zhuo Shang, Daniel Montiel, Jeffrey Maniko, Melinda A Ternei, Paula Y Calle, Christophe Lemetre, Jeremy G Owen, Sean F Brady
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences. Nature communications 10 (1) (2019)
Bradley M Hover, Seong-Hwan Kim, Micah Katz, Zachary Charlop-Powers, Jeremy G Owen, Melinda A Ternei, Jeffrey Maniko, Andreia B Estrela, Henrik Molina, Steven Park, David S Perlin, Sean F Brady
Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens. Nature microbiology 3 (4) (2018)
James Peek, Mirjana Lilic, Daniel Montiel, Aleksandr Milshteyn, Ian Woodworth, John B Biggins, Melinda A Ternei, Paula Y Calle, Michael Danziger, Thulasi Warrier, Kohta Saito, Nathaniel Braffman, Allison Fay, Michael S Glickman, Seth A Darst, Elizabeth A Campbell, Sean F Brady
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nature communications 9 (1) (2018)