Thomas R Malek

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 9

Top Topics

Regulatory T Cells

Systemic Lupus Erythematosus

Immune Response

Lipopolysaccharide Induced

Top Venues

Journal for immunotherapy of cancer

Science signaling

Cancer immunology, immunotherapy : CII

This page only lists publications with an associated author ORCID identifier.

Publications

Kathryn M LaPorte, Rosmely Hernandez, Alicia Santos Savio, Thomas R Malek
Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8 + T cells. Journal for immunotherapy of cancer 11 (6) (2023)
Rosmely Hernandez, Janika Põder, Kathryn M LaPorte, Thomas R Malek
Engineering IL-2 for immunotherapy of autoimmunity and cancer. Nature reviews. Immunology 22 (10) (2022)
Rosmely Hernandez, Kathryn M LaPorte, Sunnie Hsiung, Alicia Santos Savio, Thomas R Malek
High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity. Journal for immunotherapy of cancer 9 (9) (2022)
Alejandro Moro, Zhen Gao, Lily Wang, Aixin Yu, Sunnie Hsiung, Yuguang J Ban, Aimin Yan, Corneliu M Sologon, X Steven Chen, Thomas R Malek
Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling. Nature immunology 23 (5) (2022)
Jenny H Xie, Yifan Zhang, Martine Loubeau, Paul Mangan, Elizabeth Heimrich, Christian Tovar, Xiadi Zhou, Priyanka Madia, Michael Doyle, Shailesh Dudhgaonkar, Anjuman Rudra, Siva Subramani, James Young, Luisa Salter-Cid, Thomas R Malek, Mary Struthers
Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus. Journal of immunology (Baltimore, Md. : 1950) (2021)
Rosmely Hernandez, Kevin H Toomer, Janika Põder, Alicia Santos Savio, Sunnie Hsiung, Thomas R Malek
Sustained IL-2R signaling of limited duration by high-dose mIL-2/mCD25 fusion protein amplifies tumor-reactive CD8+ T cells to enhance antitumor immunity. Cancer immunology, immunotherapy : CII 70 (4) (2020)
Sunnie Hsiung, Alejandro Moro, Yuguang Ban, Xi Chen, Alicia Santos Savio, Rosmely Hernandez, Thomas R Malek
Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells. ImmunoHorizons 4 (12) (2020)
Natasha C Ward, Jen Bon Lui, Rosmely Hernandez, Liping Yu, Mary Struthers, Jenny Xie, Alicia Santos Savio, Connor J Dwyer, Sunnie Hsiung, Aixin Yu, Thomas R Malek
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms. Diabetes 69 (11) (2020)
Connor J Dwyer, Allison L Bayer, Carmen Fotino, Liping Yu, Cecilia Cabello-Kindelan, Natasha C Ward, Kevin H Toomer, Zhibin Chen, Thomas R Malek
Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice. Science signaling 10 (510) (2017)