p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice.
Xiaochen HeAubrey C CantrellQuinesha A WilliamsWei GuYingjie ChenJian-Xiong ChenHeng ZengPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our data reveal the importance of p53 acetylation in coronary microvascular function, cardiac function, and remodeling and may provide a promising approach to improve hypertension-induced CMD and to prevent the transition of cardiac hypertrophy to HF.
Keyphrases
- heart failure
- coronary artery disease
- high glucose
- diabetic rats
- coronary artery
- blood pressure
- oxidative stress
- drug induced
- acute heart failure
- left ventricular
- aortic stenosis
- type diabetes
- adipose tissue
- dna methylation
- metabolic syndrome
- high fat diet induced
- transcatheter aortic valve replacement
- insulin resistance
- artificial intelligence
- cardiac resynchronization therapy
- arterial hypertension