Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma.

Jan BudcziesMartina KirchnerKlaus KluckDaniel KazdalJulia GladeMichael AllgäuerMark KriegsmannClaus-Peter HeußelFelix J HerthHauke WinterMichael MeisterThomas MuleyTorsten GoldmannStefan FröhlingMartin WermkeCornelius F WallerAmanda TufmanMartin ReckSolange PetersPeter SchirmacherMichael ThomasPetros ChristopoulosAlbrecht Stenzinger

Published in: Cancer immunology, immunotherapy : CII (2021)

Targeted gene expression profiling is a promising tool to read out tumor microenvironment characteristics from routine diagnostic lung cancer biopsies. Significant immune reactivity including specific immunosuppressive characteristics in ALK- and EGFR-positive lung ADC, but not a total absence of immune infiltration supports further clinical evaluation of immune-modulators as partners of ICB in such tumors.

Keyphrases

gene expression
small cell lung cancer
epidermal growth factor receptor
advanced non small cell lung cancer
tyrosine kinase
dna methylation
small molecule
clinical practice
single cell
cancer therapy
drug delivery
hiv infected
ultrasound guided