Monocytes from male patients with ankylosing spondylitis display decreased osteoclastogenesis and decreased RANKL/OPG ratio.
V F CaparboC G S SaadJ C MoraesA J de Brum-FernandesRosa Maria Rodrigues PereiraPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2018)
Monocytes from male AS patients display a lower capacity to generate osteoclasts in vitro compared to cells from controls. Osteoclastogenesis was negatively correlated with disease duration. This finding supports the idea that osteoclasts play a role in the physiopathology of bone disease in AS patients.
Keyphrases
- end stage renal disease
- ankylosing spondylitis
- bone loss
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- rheumatoid arthritis
- dendritic cells
- immune response
- inflammatory response
- systemic lupus erythematosus
- lps induced
- patient reported outcomes
- postmenopausal women