Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway.

Zong-Jian LiuYuan-Yuan RanShu-Yan QieWei-Jun GongFu-Hai GaoZi-Tong DingJia-Ning Xi

Published in: CNS neuroscience & therapeutics (2020)

Melatonin treatment ameliorates brain damage at least partially through shifting microglia phenotype from pro-inflammatory to anti-inflammatory polarity in a STAT3-dependent manner.

Keyphrases

anti inflammatory
inflammatory response
cell proliferation
neuropathic pain
oxidative stress
atrial fibrillation
signaling pathway
resting state
combination therapy
cerebral ischemia