Synthesis of 3-Substituted 3-Bromo-1-phenylallenes from Alkynylcycloheptatrienes.
Marie VayerRégis GuillotChristophe BourVincent GandonPublished in: The Journal of organic chemistry (2018)
A new method has been developed for the preparation of 3-bromo-1-phenylallenes from 7-alkynylcycloheptatrienes and N-bromosuccinimide. Trisubstituted bromoallenes were obtained at room temperature in moderate to excellent yields. Functionalization of the carbon-bromine bond via Pd- or Cu-catalyzed cross-coupling reactions easily provided substituted allenes.