Detection of anti-domain I antibodies by chemiluminescence enables the identification of high-risk antiphospholipid syndrome patients: A multicenter multiplatform study.
Dongmei YinWalid ChayouaHilde KelchtermansPhilip G de GrootGary W MooreJean-Christophe GrisStéphane ZuilyJacek MusialBas de LaatKatrien M J DevreesePublished in: Journal of thrombosis and haemostasis : JTH (2020)
Detection of anti-DI IgG resulted in higher ORs for clinical manifestations than the current APS classification criteria. Regardless of the platform used to detect anti-β2GPI/anti-CL, addition of anti-DI IgG measured by QUANTA Flash® did not improve the clinical associations, possibly due to reduced exposure of the pathogenic epitope of DI. Our results demonstrate that anti-DI IgG potentially helps in identifying high-risk patients.