Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma.

Weiwei TangGuangshun SunGu-Wei JiTingting FengQian ZhangHengsong CaoWenhao WuXiaoyi ZhangChuan LiuHanyuan LiuTian HuangLi LiuYongxiang XiaXuehao Wang

Published in: Journal for immunotherapy of cancer (2023)

ScRNA-seq atlas revealed an FABP1-dependent immunosuppressive environment in HCC. Orlistat significantly inhibited FABP1 activity, while the combination of anti-PD-1 could synergistically treat HCC progression. This study identified new treatment targets and strategies for HCC progression, contributing to patients with advanced HCC from new perspectives.

Keyphrases

single cell
rna seq
binding protein
high throughput
combination therapy
dna methylation
smoking cessation