A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer.

Richard J RobbinsJessica S ThomasPatricia Mejia OsunaJawairia Shakil

Published in: Case reports in endocrinology (2020)

We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common BRAF mutation may independently drive neoplastic transformation of human parafollicular C cells.

Keyphrases

metastatic colorectal cancer
wild type
case report
endothelial cells
induced apoptosis
late onset
cell cycle arrest
oxidative stress
cell death
amyotrophic lateral sclerosis