Hypoxia-inducible factor-1α regulates the interleukin-6 production by B cells in rheumatoid arthritis.

Chaofan FanJia LiYixuan LiYuyang JinJiaqi FengRuru GuoXinyu MengDongcheng GongQian ChenFang DuChunyan ZhangLiangjing LuJun DengXiao-Xiang Chen

Published in: Clinical & translational immunology (2023)

This study highlights the role of B cells in producing IL-6 and the regulation of this production by HIF-1α in patients with RA. Targeting HIF-1α might provide a new therapeutic strategy for treating RA.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
interstitial lung disease
endothelial cells
systemic lupus erythematosus
systemic sclerosis
cancer therapy
drug delivery