What clindamycin dose should be administered by continuous infusion during combination therapy with rifampicin? A prospective population pharmacokinetics study.

Léo MimramSophie MagréaultYounes KerroumiDominique SalmonBenjamin KablySimon MarmorAnne-Sophie JannotVincent JullienValérie Zeller

Published in: The Journal of antimicrobial chemotherapy (2023)

Our results support continuous infusion of 4200 mg of clindamycin/24 h, in combination with rifampicin. This high-dose regimen requires therapeutic drug monitoring-guided dose adaptation.

Keyphrases

combination therapy
high dose
low dose
mycobacterium tuberculosis
pulmonary tuberculosis
stem cell transplantation