Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events.
Feitong WuMarkus JuonalaDavid R JacobsStephen R DanielsMika KÄhÖnenJessica G WooAlan R SinaikoJorma S A ViikariLydia A BazzanoTrudy L BurnsJulia SteinbergerElaine M UrbinaAlison J VennOlli T RaitakariTerence DwyerCostan G MagnussenPublished in: Circulation (2023)
Childhood non-HDL-C and LDL-C levels are associated with ASCVD events in midlife. Non-HDL-C is better than LDL-C in predicting adult ASCVD events, particularly among individuals who had normal LDL-C but elevated non-HDL-C. These findings suggest that both non-HDL-C and LDL-C are useful in identifying children at higher risk of ASCVD events, but non-HDL-C may provide added prognostic information when it is discordantly higher than the corresponding LDL-C and has the practical advantage of being determined without a fasting sample.