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Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events.

Feitong WuMarkus JuonalaDavid R JacobsStephen R DanielsMika KÄhÖnenJessica G WooAlan R SinaikoJorma S A ViikariLydia A BazzanoTrudy L BurnsJulia SteinbergerElaine M UrbinaAlison J VennOlli T RaitakariTerence DwyerCostan G Magnussen
Published in: Circulation (2023)
Childhood non-HDL-C and LDL-C levels are associated with ASCVD events in midlife. Non-HDL-C is better than LDL-C in predicting adult ASCVD events, particularly among individuals who had normal LDL-C but elevated non-HDL-C. These findings suggest that both non-HDL-C and LDL-C are useful in identifying children at higher risk of ASCVD events, but non-HDL-C may provide added prognostic information when it is discordantly higher than the corresponding LDL-C and has the practical advantage of being determined without a fasting sample.
Keyphrases
  • low density lipoprotein
  • cardiovascular events
  • childhood cancer
  • cardiovascular disease
  • young adults
  • healthcare
  • type diabetes
  • insulin resistance
  • health information