Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells.

Felipe SerranoMaria García-BravoMarina BlazquezJosema TorresJose V CastellJose C SegoviaRoque Bort

Published in: Stem cell research & therapy (2016)

This study highlights the dangers of using pluripotency factors in reprogramming strategies when fate-conversion factors are silenced in vivo, and urges us to perform extensive tumorigenic tests in reprogrammed cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
cell death
signaling pathway