Cross-Validation of a Multiplex LC-MS/MS Method for Assaying mAbs Plasma Levels in Patients with Cancer: A GPCO-UNICANCER Study.

Clémence Marin Nihel KhoudourAurélien MilletDorothée LebertPauline BrosFabienne ThomasDavid TernantBruno LacarelleJérôme Guitton Joseph CiccoliniBenoit Blanchet

Published in: Pharmaceuticals (Basel, Switzerland) (2021)

We developed and cross-validated a simple, accurate and precise method that allows the assay of up to 7 mAbs. Furthermore, the present method is the first to offer a simultaneous quantification of three immune checkpoint inhibitors likely to be associated in patients.

Keyphrases

end stage renal disease
high throughput
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
mass spectrometry
high resolution
simultaneous determination
liquid chromatography
patient reported
real time pcr