EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma.
Ritu ChaudharyRobbert J C SlebosLeenil C NoelFeifei SongMaria I PooleDirk S HoeningJuan C Hernandez-PreraJosé R Conejo-GarciaJosé A Guevara-PatiñoXuefeng WangMengyu XieAik Choon TanChristine H ChungPublished in: Cancer research communications (2023)
While the hypoxic and immunosuppressive TME of HNSCC has been well described, comprehensive evaluation of the immune cell components and signaling pathways contributing to immunotherapy resistance has been poorly characterized. We further identified additional molecular determinants and potential therapeutic targets of the hypoxic TME to fully leverage currently available targeted therapies that can be administered with immunotherapy.
Keyphrases
- small cell lung cancer
- signaling pathway
- epidermal growth factor receptor
- immune response
- tyrosine kinase
- endothelial cells
- dendritic cells
- metastatic colorectal cancer
- locally advanced
- squamous cell carcinoma
- radiation therapy
- genome wide identification
- single molecule
- human health
- cell proliferation
- oxidative stress
- transcription factor