Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation.
Shriprasad R DeshpandeSteven D ZangwillMarc E RichmondSteven J KindelJacob N SchroderNunzio GaglianelloDavid P BichellMark A WiggerKenneth R KnechtPhillip T ThrushWilliam T MahlePaula E NorthPippa M SimpsonLiyun ZhangMahua DasguptaAoy Tomita-MitchellMichael E MitchellPublished in: Pediatric transplantation (2024)
The study suggests that pediatric patients with rejection show higher levels of circulating df-cfDNA compared to adults and supports the specific cut points for clinical use in pediatric and adult patients with overall acceptable performance.
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