A pig model of tunneled dialysis catheter (TDC) infection and dysfunction: Opportunities for therapeutic innovation.

Diego Celdran-Bonafonte Lihua H Wang Aous JarroujBegona Campos-NaciffJaroslav JandaPrabir Roy-Chaudhury

Published in: The journal of vascular access (2021)

The described model represents a reliable and reproducible large animal model of catheter dysfunction and bloodstream infection, which recreates all the main complications of TDC's and so could be used as a validated large animal model to develop new therapies for TDC related infection, thrombosis/dysfunction and central venous stenosis.

Keyphrases

oxidative stress
chronic kidney disease
pulmonary embolism
risk factors
ultrasound guided
end stage renal disease
klebsiella pneumoniae