Improvement of Severe COVID-19 in an Elderly Man by Sequential Use of Antiviral Drugs.
Masakiyo YatomiTomonori TakazawaKunio YanagisawaMasafumi KanamotoYusuke MatsuiHiroyuki TsukagoshiNobuhiro SarukiShigeru SaitoYutaka TokueToshitaka MaenoPublished in: Case reports in infectious diseases (2020)
Although a variety of existing drugs are being tested for patients with coronavirus disease 2019 (COVID-19), no efficacious treatment has been found so far, particularly for severe cases. We report successful recovery in an elderly patient with severe pneumonia requiring mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Despite administration of multiple antiviral drugs, including lopinavir/ritonavir, chloroquine, and favipiravir, the patient's condition did not improve. However, after administration of another antiviral drug, remdesivir, we were able to terminate invasive interventions, including ECMO, and subsequently obtained negative polymerase chain reaction results. Although further validation is needed, remdesivir might be effective in treating COVID-19.
Keyphrases
- coronavirus disease
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- mechanical ventilation
- respiratory failure
- sars cov
- drug induced
- early onset
- respiratory syndrome coronavirus
- case report
- middle aged
- intensive care unit
- physical activity
- community dwelling
- emergency department
- smoking cessation
- community acquired pneumonia