Roadmap for Precision preclinical x-ray radiation studies.
Frank VerhaegenKarl T ButterworthAnthony J ChalmersRob P CoppesDirk de RuysscherSophie DobiaschJohn D FenwickPatrick V GrantonStefan H J HeijmansMark A HillConstantinos KoumenisKirsten LauberBrian MarplesKatia ParodiLucas C G G PersoonNick StautAnna SubielRianne D W VaesStefan J van HoofIoannis L VerginadisJan J WilkensKaye J WilliamsGeorge D WilsonLudwig J DuboisPublished in: Physics in medicine and biology (2022)
This Roadmap paper covers the field of precision preclinical radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolutions in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and inverse translation are discussed.