The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway.

Charlotte JendresenVibeke ÅrskogMichael R DawsLars N G Nilsson

Published in: Journal of neuroinflammation (2017)

An ApoE-mediated dose-dependent signal transduction through TREM2 in reporter cells was demonstrated, and a TREM2-binding region in ApoE was identified. The relevance of an ApoE-TREM2 receptor signaling pathway to Alzheimer's disease is discussed.

Keyphrases

cognitive decline
signaling pathway
induced apoptosis
risk factors
mild cognitive impairment
high fat diet
pi k akt
cell cycle arrest
epithelial mesenchymal transition
endoplasmic reticulum stress
binding protein
crispr cas
oxidative stress
skeletal muscle
transcription factor