Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer.
Xiao-Mei LiMao-Ting LiNi JiangYa-Chen SiMeng-Mei ZhuQiao-Yuan WuDong-Chen ShiHui ShiQing LuoBing YuPublished in: Cancer management and research (2021)
MAPK1, NR3C1, NOS1, NOS2 and NOS3 were identified as the putative targets of sinomenine for treating breast cancer. NR3C1 was preliminarily confirmed as a target of sinomenine in two breast cancer cell lines, xenograft tumor models and human breast cancer specimens. These data indicated that the network pharmacology-based prediction of sinomenine targets for treating breast cancer could be reliable.