miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice.
Yitian LuMaozhu LiuXiangna GuoPeng WangFanning ZengHaitao WangJing TangZaisheng QinTao TaoPublished in: CNS neuroscience & therapeutics (2023)
miR-26a-5p is a promising therapy for CFA-induced inflammatory pain. Both intrathecal and subcutaneous injections provide relief for inflammatory pain. miR-26a-5p regulated noncanonical Wnt signaling to be involved in analgesia partly through antineuroinflammation, suggesting a pain-alleviating effect via noncanonical Wnt signaling pathway in the CFA-induced inflammatory pain model in vivo.
Keyphrases
- chronic pain
- pain management
- neuropathic pain
- oxidative stress
- high glucose
- diabetic rats
- signaling pathway
- stem cells
- drug induced
- cell proliferation
- postoperative pain
- spinal cord
- spinal cord injury
- endothelial cells
- ultrasound guided
- epithelial mesenchymal transition
- adipose tissue
- skeletal muscle
- endoplasmic reticulum stress