Spatio-Temporally Reporting Dose-Dependent Chemotherapy via Uniting Dual-Modal MRI/NIR Imaging.
Yiyu MaChenxu YanZhi-Qian GuoGuang TanDechao NiuYongsheng LiWei-Hong ZhuPublished in: Angewandte Chemie (International ed. in English) (2020)
Unpredictable in vivo therapeutic feedback of hydroxyl radical (. OH) efficiency is the major bottleneck of chemodynamic therapy. Herein, we describe novel Fenton-based nanotheranostics NQ-Cy@Fe&GOD for spatio-temporally reporting intratumor . OH-mediated treatment, which innovatively unites dual-channel near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces the dose distribution of Fenton-based iron oxide nanoparticles (IONPs) with high-spatial resolution, meanwhile timely fluorescence signal quantifies . OH-mediated therapeutic response with high spatio-temporal resolution. NQ-Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and . OH-induced NQO1 enzyme in living cells and tumor-bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio-temporally reporting chemodynamic therapy, so as to manipulate dose-dependent therapeutic process.
Keyphrases
- magnetic resonance imaging
- single molecule
- contrast enhanced
- living cells
- fluorescent probe
- diffusion weighted imaging
- adverse drug
- iron oxide nanoparticles
- photodynamic therapy
- computed tomography
- hydrogen peroxide
- stress induced
- wastewater treatment
- fluorescence imaging
- high resolution
- drug release
- high glucose
- magnetic resonance
- type diabetes
- stem cells
- endothelial cells
- metal organic framework
- reactive oxygen species
- nitric oxide
- cell therapy
- adipose tissue
- oxidative stress
- aqueous solution
- replacement therapy