Drinking water nitrate and risk of pregnancy loss: a nationwide cohort study.
Ninna Hinchely EbdrupJörg SchullehnerUlla Breth KnudsenZeyan LiewAnne Marie Ladehoff ThomsenJulie LyngsøBjørn BayLinn Håkonsen ArendtPernille Jul ClemmensenTorben SigsgaardBirgitte HansenCecilia Høst Ramlau-HansenPublished in: Environmental health : a global access science source (2022)
No association was seen between drinking water nitrate and the risk of pregnancy loss when investigating the exposure as a categorical variable. When we modelled the exposure as a continuous variable, a dose-dependent association was found between drinking water nitrate exposure in the first trimester and the risk of pregnancy loss. Very early pregnancy losses were not considered in this study, and whether survival bias influenced the results should be further explored.