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Prenylated Flavonoids from the Roots of Tephrosia rhodesica.

Yoseph AtilawLois Muiva-MutisyaJonathan BogaertsSandra DuffyArto ValkonenMatthias HeydenreichVicky M AveryKari T RissanenMáté ErdélyiAbiy Yenesew
Published in: Journal of natural products (2020)
Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5-15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
Keyphrases
  • plasmodium falciparum
  • molecular docking
  • high resolution
  • oxidative stress
  • room temperature
  • anti inflammatory
  • magnetic resonance
  • ms ms
  • solid state
  • magnetic resonance imaging
  • ionic liquid
  • cell wall