A pharmacovigilance study on antiepileptic medications in a paediatric hospital in Italy.

Nicoletta Monti GuarnieriAdriana PompilioCarla MariniGiovanni Battista OrtenziEmanuela AndrescianiAngela Maria Felicita GarzoneMaria Consuelo IeracitanoCarlo Polidori

Published in: European journal of hospital pharmacy : science and practice (2022)

During the 3-year observation period, 6% of epileptic patients on ASMs showed one or more ADRs. Carbamazepine was responsible for about a quarter of these reactions, two of which were serious. Half of the ADRs occurred with polytherapy, which often included valproic acid and stiripentol. It is to be hoped that such active pharmacovigilance through the collaboration of hospital pharmacists and physicians will serve to improve the management of treatment.

Keyphrases

adverse drug
end stage renal disease
healthcare
ejection fraction
primary care
chronic kidney disease
emergency department
prognostic factors
peritoneal dialysis
acute care
drug induced
patient reported outcomes
smoking cessation
combination therapy
replacement therapy