Population pharmacokinetics of treosulfan in paediatric patients undergoing hematopoietic stem cell transplantation.

M Y Eileen C van der Stoep Juliette Zwaveling Alice BertainaF LocatelliHenk-Jan Guchelaar Arjan C Lankester Dirk Jan A R Moes

Published in: British journal of clinical pharmacology (2019)

This study provides a treosulfan population PK model in children and captures the developmental changes in clearance. A 3-point LSM allows for accurate and precise estimation of treosulfan exposure.

Keyphrases

patients undergoing
young adults
emergency department
high resolution