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Utility of MALDI-TOF MS for determination of species identity and blood meal sources of primary malaria vectors on the Kenyan coast.

Jonathan KarisaKelly OmindeMercy TuweiBrian BartilolZedekiah OndiekiHarun MusaniCaroline WanjikuKioko MwikaliLawrence BabuMartin K RonoMumin EminovCharles M MbogoPhilip BejonJoseph MwangangiMaureen LarocheMarta Ferreira Maia
Published in: Wellcome open research (2024)
This study provides further evidence of the discriminative power of MALDI-TOF MS to identify sibling species and blood meal source of Afrotropical malaria vectors, further supporting its utility in entomological surveillance. The low cost per sample (<0.2USD) and high throughput nature of the method represents a cost-effective alternative to molecular methods and could enable programs to increase the number of samples analysed and therefore improve the data generated from surveillance activities.
Keyphrases
  • low cost
  • public health
  • high throughput
  • mass spectrometry
  • plasmodium falciparum
  • drinking water
  • electronic health record
  • big data
  • single cell
  • high resolution
  • solid phase extraction
  • molecularly imprinted