A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy.

Nicolás M CasellasGaole Dai Evelyn Y XueAlba FonsecaDennis K P Ng Miguel Garcia-Iglesias Tomás Torres

Published in: Chemical communications (Cambridge, England) (2022)

A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC 50 values of as low as 1.2 μM.

Keyphrases

photodynamic therapy
fluorescence imaging
molecular docking
walled carbon nanotubes
optical coherence tomography
molecular dynamics simulations
quantum dots