Sirtuins and Neuropeptide y downregulation in Flinders Sensitive Line Rat Model of Depression.

Miranda StiernborgPaschalis Efstathopoulos Andreas LennartssonCatharina LavebrattAleksander A Mathé

Published in: Acta neuropsychiatrica (2021)

i. This is the first demonstration that SIRT1 and SIRT2 are changed in brain of FSL, a rat model of depression ; ii. The changes are age dependent; iii. Sirtuins are potential targets for treatment of age-related neurodegenerative diseases.

Keyphrases

depressive symptoms
oxidative stress
sleep quality
ischemia reperfusion injury
cell proliferation
signaling pathway
white matter
resting state
physical activity
risk assessment
replacement therapy
blood brain barrier
smoking cessation