Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis.

Michal HlavacAnnika DwucetRichard Eric KastJens EngelkeMike-Andrew WesthoffMarkus D SiegelinKlaus-Michael DebatinChristian Rainer WirtzMarc-Eric HalatschGeorg Karpel-Massler

Published in: Cellular oncology (Dordrecht) (2019)

Our data indicate that concomitant inhibition of RAC1 and Bcl-2/Bcl-xL induces pro-apoptotic and anti-migratory glioblastoma phenotypes as well as synergistic anti-neoplastic activities. The clinical efficacy of this inhibitory therapeutic strategy warrants further evaluation.

Keyphrases

cell death
anti inflammatory
cell cycle arrest
big data
electronic health record
cancer therapy
machine learning
signaling pathway
artificial intelligence