Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model.

Jingjing MengYaa F AbuYue ZhangYuyin ZhouYun XieYan YanJunyi TaoSundaram RamakrishnanChi ChenSabita Roy

Published in: British journal of pharmacology (2022)

Gut microbiota play a significant role in opioid and chemotherapeutic agent drug-drug interactions. Inhibition of gut microbial glucuronidase may also prevent adverse GI effects of CPT-11 in patients on opioids.

Keyphrases

chronic pain
pain management
end stage renal disease
microbial community
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
oxidative stress
drug induced
patient reported