Endothelial NLRP3 inflammasome regulation in atherosclerosis.
Shuai GuoLitao WangKaixiang CaoZiling LiMingchuan SongShuqi HuangZou LiCailing WangPeiling ChenYong WangXiaoyan DaiXianglin ChenXiaodong FuDu FengJun HeYuqing HuoYiming XuPublished in: Cardiovascular research (2024)
Our findings highlight the existence of a glycolysis-dependent NADH/CtBP/FOXP1-transrepression pathway that regulates endothelial NLRP3 inflammasome activation in atherogenesis. This pathway represents a potential target for selective PFKFB3 inhibitors or strategies aimed at disrupting CtBP1 oligomerization to modulate atherosclerosis.