Association between Interleukin-6 Gene Polymorphism ( rs1800795 and rs1800796 ) and Type 2 Diabetes Mellitus in a Ghanaian Population: A Case-Control Study in the Ho Municipality.

Christian Obirikorang Sylvester Yao LokpoWilliam K B A OwireduLinda Ahenkorah Fondjo James Osei-Yeboah Kwabena Obeng DueduEsther Ngozi AdejumoSamuel AmetepeEvans Asamoah AduShadrack Asiedu CoffieEmmanuel Nattah Mawuli Priscilla Essandoh Precious Kwablah Kwadzokpui

Published in: BioMed research international (2024)

The GC genotype and mutant C allele are risk genetic variants associated with type 2 DM in the Ghanaian population. The rs1800796 GC variant, dietary sugar intake, and exercise status appear to contribute significantly to the variations in circulating IL-6 levels but with weak effect sizes.

Keyphrases

glycemic control
physical activity
type diabetes
cardiovascular disease
adipose tissue
cell proliferation
mass spectrometry
signaling pathway