Prediction of spontaneous preterm birth and preterm prelabor rupture of membranes using maternal factors, obstetric history and biomarkers of placental function at 11-13 weeks.

C P H Chiu Qiaoli Feng P Chaemsaithong Daljit Singh SahotaY Y LauY K YeungL W YimJ P W ChungLiona Chiu Yee Poon

Published in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2022)

We demonstrated that low levels of maternal serum PAPP-A and PlGF in the first trimester are associated with increased risks of sPTB and PPROM at < 37 weeks. However, further research is needed to identify additional biomarkers to improve the screening performance of the combined model that includes maternal risk factors, PAPP-A and PlGF before clinical application. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.

Keyphrases

gestational age
birth weight
preterm birth
low birth weight
risk factors
pregnancy outcomes
pregnant women
magnetic resonance imaging
computed tomography