Elevation of inflammatory S100A8/S100A9 complexes in intracranial aneurysms.
Antonius Mattheus de KorteRené AquariusThomas VoglJohannes RothRonald H M A BartelsHieronymus D BoogaartsPeter L E M van LentJoost De VriesPublished in: Journal of neurointerventional surgery (2020)
Venous S100A8/A9 levels are elevated in patients with both rIAs and uIAs compared with healthy controls and likely represents aneurysm wall inflammation. S100A8/A9 causes macrophage-induced inflammation and degeneration of the vessel wall which might explain higher intra-aneurysmal S100A8/A9 levels found in rIAs than in uIAs.