Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells.
Nobuo WatanabeMasako KidokoroMakiko TanakaShigeaki InoueTomoatsu TsujiHisako AkatuskaChisa OkadaYumi IidaYoshinori OkadaYusuke SuzukiTakehito SatoTakashi YahataNoriaki HirayamaYoshihide NakagawaSadaki InokuchiPublished in: Cancer cell international (2020)
These results suggested that, while PDPN seems to function in favor of maintaining the epithelial state of this cell line, it is indispensable for platelet-mediated induction of particular mesenchymal marker genes as well as the potentiation of motility and invasion capacity.
Keyphrases
- gene expression
- induced apoptosis
- biofilm formation
- cell cycle arrest
- dna methylation
- stem cells
- bone marrow
- high glucose
- single cell
- genome wide
- diabetic rats
- cell therapy
- drug induced
- endoplasmic reticulum stress
- cell death
- oxidative stress
- pseudomonas aeruginosa
- low grade
- cystic fibrosis
- cell proliferation
- genome wide identification
- mesenchymal stem cells
- endothelial cells