Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets.

Defne Bayik Cynthia F Bartels Katreya Lovrenert Dionysios C Watson Duo Zhang Kristen E Kay Juyeun Lee Adam Lauko Sarah Johnson Alice Lo Daniel J Silver Mary McGraw Matthew M Grabowski Alireza M Mohammadi Filippo Veglia Yi Fan Michael A Vogelbaum Peter C Scacheri Justin D Lathia

Published in: Cancer research (2022)

Epigenetic profiling uncovers cell adhesion programming as a regulator of the tumor-promoting functions of monocytic myeloid-derived suppressor cells in glioblastoma, identifying therapeutic targets that modulate the immune response and suppress tumor growth.

Keyphrases

cell adhesion
immune response
single cell
induced apoptosis
cell cycle arrest
dna methylation
gene expression
cell therapy
peripheral blood
transcription factor
endoplasmic reticulum stress
stem cells
toll like receptor
signaling pathway
cell death
mesenchymal stem cells
bone marrow
pi k akt