[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.
Jelle van den AmeeleYoung HongRoido ManavakiAntonina KouliHeather BiggsZoe MacIntyreRita HorvathPatrick Yu-Wai-ManEvan ReidCaroline H Williams-GrayEdward T BullmoreFranklin I AigbirhioTim FryerPatrick ChinneryPublished in: Neurology (2021)
This study provides Class III evidence that PET-MR brain imaging with TSPO radioligands identifies mitochondrial pathology.
Keyphrases
- oxidative stress
- high resolution
- pet imaging
- computed tomography
- white matter
- resting state
- pet ct
- positron emission tomography
- cerebral ischemia
- multiple sclerosis
- magnetic resonance imaging
- mass spectrometry
- small molecule
- gene expression
- fluorescence imaging
- blood brain barrier
- contrast enhanced
- brain injury
- photodynamic therapy