Chronic kidney disease increases the susceptibility to negative effects of low and high potassium intake.
Martin GritterKuang-Yu WeiRosa D WoudaUsha M Musterd-BhaggoeKyra L DijkstraJesper KersChristian RamakersLiffert VogtMartin H de BorstAlexander H J DanserEwout J HoornJoris I RotmansPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
CKD increases the susceptibility to negative effects of low and high K+ diets in male rats, although the injury patterns are different. The low K+ diet caused inflammation, nephromegaly and kidney function decline, whereas the high K+ diet caused hypertension, hyperaldosteronism and kidney fibrosis. High KCitrate attenuated the hypertensive but not the pro-fibrotic effect of high KCl, which may be attributable to K+-induced aldosterone secretion. Our data suggest that especially in people with CKD it is important to identify the optimal threshold of dietary K+ intake.