Clearance of ctDNA in triple-negative and HER2-positive breast cancer patients during neoadjuvant treatment is correlated with pathologic complete response.
Nikaoly CiriacoEsther Zamora AdelantadoSantiago Escriva-de-RomaniIgnacio Miranda GómezJose JimenezCristina SauraHillary SloaneAnna StarusJohannes FredebohmLucy GeorgievaGraham SpeightFrederick JonesSantiago Ramón Y CajalMartín Espinosa-BravoVicente PegPublished in: Therapeutic advances in medical oncology (2022)
These findings prompt further research of the value of ctDNA for non-invasive prediction of clinical/pathological response, raising the possibility of sparing surgery following NAC in selected BC patients.