IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma.
Turan AghayevAleksandra M MazitovaJennifer R FangIuliia O PeshkovaMatthew RauschMan Hsin HungKerry F WhiteRicard MasiaElizaveta K TiterinaAliia R FatkhullinaIsabelle CousineauSimon TurcotteDmitry ZhigarevAnastasiia MarchenkoSvetlana KhoziainovaPeter MakhovYin Fei TanAndrew V KossenkovDavid L WiestJohn StaggXin Wei WangKerry S CampbellAmiran K DzutsevGiorgio TrinchieriJonathan A HillSergei I GrivennikovEkaterina K KoltsovaPublished in: Cancer discovery (2022)
HCC, the most common form of liver cancer, is characterized by a poor survival rate and limited treatment options. The discovery of a novel IL27-dependent mechanism controlling anticancer cytotoxic immune response will pave the road for new treatment options for this devastating disease. This article is highlighted in the In This Issue feature, p. 1825.