Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1.
Jung Seok HwangEunsu KimJinwoo HurTaek Joon YoonHan-Geuk SeoPublished in: British journal of pharmacology (2020)
RNF219 is involved in a novel mechanism to stabilize SIRT1 protein by protein-protein interaction, leading to the resolution of cellular inflammation. These observations provide new insights into the function of RNF219 in modulation of cellular inflammation, and may aid and encourage the development of new anti-inflammatory drugs.